Studies and research have found that proton pump inhibitors (PPIs) have been associated with an increased risk of kidney damage, kidney failure, and other health damage. While there is no way to reverse any damage these drugs have caused, victims can file lawsuits against negligent pharmaceutical companies to gain compensation.
Patients who have taken or are currently taking PPI drugs such as Prilosec and Nexium are seeking legal help for compensation for their suffering, medical bills, and lost wages. Broughton Partners’ attorney case generation services connect retained plaintiffs with personal injury lawyers looking for PPI lawsuit cases. Your law firm can get PPI lawsuit leads delivered with relevant case documents by contacting our team at (912)-304-4444 or filling out a quick online form for a free consultation.
What Are Proton Pump Inhibitors (PPIs)?
PPIs are drugs associated with a group of drugs that are used to treat gastroesophageal reflux disorder (GERD) and various issues related to stomach acid. These drugs have become the number one selling drugs in America, and PPI drugs are available as prescribed medication and also as over-the-counter medications. They are an effective method of treatment for gastric acid diseases.
Proton pumps in the human body are responsible for creating hydrochloric acid in the stomach. This hydrochloric acid in the stomach is needed to digest foods. There is a muscle between the esophagus and the stomach, and in some instances, the muscle does not close properly. This results in stomach acid rising towards the throat, causing pain in the chest or esophagus areas. What the proton pump inhibitor drugs do to help this issue is to reduce the amount of hydrochloric acid produced by the proton pumps.
List of Popular PPI Drugs
- Omeprazole (Prilosec, Prilosec OTC)
- Aspirin and Omeprazole (Yosprala)
- Lansoprazole (Prevacid, Prevacid IV, Prevacid 24-Hour)
- Dexlansoprazole (Dexilent and Dexilent Solutab)
- Rabeprazole (Aciphex, Aciphex Sprinkle)
- Pantoprazole (Protonix)
- Esomeprazole (Nexium, Nexium IV, Nexium 24 HR)
- Esomeprazole Magnesium/Naproxen (Vimovo)
- Omeprazole/Sodium Bicarbonate (Zegerid, Zegerid OTC)
Who Needs PPI Drugs?
Proton pump inhibitor drugs are prescribed and bought over-the-counter by those who experience an overproduction of stomach acid or are exacerbated by stomach acid. People who suffer from common symptoms such as heartburn also use proton pump inhibitor drugs. The use of PPIs can be related to the treatment of the following conditions:
- Acid Reflux (also called gastroesophageal reflux disease (GERD))
This condition occurs when the stomach acid rises to the esophagus and causes heartburn. Acid reflux, or GERD, is the most common reason why people use proton pump inhibitor drugs. People with GERD will typically experience chest pain, throat pain, regurgitation, and nausea. Complicated cases of GERD will cause ulcers, Barrett’s esophagus, asthma, laryngeal inflammation, lung infection, and fluid collection in the sinuses.
- Zollinger-Ellison Syndrome
This condition is rare and is associated with issues of the digestive system and the overproduction of stomach acid. The main symptom of Zollinger-Ellison Syndrome is the development of tumors called gastrinomas. These tumors form in the pancreas and upper area of the small intestine or duodenum. Symptoms of Zollinger-Ellison Syndrome include nausea, bloating, gas, weight loss, loss of appetite, and vomiting.
- Erosive Esophagitis
This condition occurs when there is inflammation of the esophagus caused by stomach acid. Erosive esophagitis causes pain when swallowing and pain in the chest. Symptoms of erosive esophagitis include acid regurgitation, heartburn, pain or difficulty when swallowing, chest pain, and food impaction.
- Helicobacter Pylori Infection
This infection occurs when the bacteria called Helicobacter pylori or H. pylori infects the stomach. About 30 to 40 percent of people in America get a Helicobacter pylori infection, and it is most common during childhood. Symptoms of Helicobacter pylori infections include stomach pain, loss of appetite, nausea, gas, bloating, and weight loss.
- Duodenal and Stomach Ulcers
The duodenum is the upper part of the small intestine and a duodenal ulcer forms in the lining of the duodenum. Helicobacter pylori is a major cause of duodenal ulcers because these bacteria can cause your duodenum lining to become inflamed and vulnerable to ulcers.
Common Side Effects of PPI Drugs
While proton pump inhibitors are effective drugs, they can also be quite harmful if not taken as directed. It is recommended that high doses of any PPI drug are to be avoided to avert severe long-term side effects. Some common side effects of PPI drugs include the following:
- Stomach Pain
- Dry Mouth
Long-Term Severe Side Effects of PPI Drugs
The drug interactions of consumers buying over-the-counter drugs are difficult to regulate. That is why it is imperative for pharmaceutical companies to make sure consumers are made aware of all potential side effects. It is also essential for these pharmaceutical companies to perform all clinical tests on the drug and ensure that they are ready for general purchase.
Unfortunately, pharmaceutical companies are more often motivated by profits and will do anything they can to quickly get their product out in the market. They may even provide clinical data to the FDA that isn’t 100% accurate. As a result, their drugs are made widely available to the public before all the side effects are clearly understood.
Here are some long-term severe side effects that are potentially related to the use of PPIs:
- Clostridium Difficile Infection
Clostridium Difficile is a bacteria that causes diarrhea and other harsh intestinal conditions. A safety announcement was made by the FDA in 2012 stating that the use of proton pump inhibitors may be associated with an increased risk of Clostridium Difficile.
- Bone Fractures
Some bone fractures occur from high force or impact, while other bone fractures occur from a medical condition that weakens the bones. Another safety announcement was made by the FDA in 2011 stating that long-term use of prescription proton pump inhibitor drugs may cause low serum magnesium levels. Low magnesium levels result in weak bones, thus making people more susceptible to bone fractures.
- Chronic Kidney Disease
Chronic Kidney Disease relates to the kidneys’ gradual loss of functionality over time and this damage to the kidneys is associated with the use of proton pump inhibitor drugs. Patients who have regularly taken PPI drugs over a long period of time have a greater risk of kidney disease. According to a study published in the U.S. National Library of Medicine’s National Institutes of Health, patients that use proton pump inhibitor drugs such as Prilosec have about a 20 to 50 percent higher risk of chronic kidney failure.
- Heart Attacks
A study by Houston Methodist and Stanford University found that PPI drugs increase the risk of heart attacks. Using PPI drugs could potentially interfere with the body’s blood vessels, which could result in heart issues. Dr. John Cooke of the Houston Methodist Research Institute found that drugs such as Nexium raise the general population’s risk of heart attacks by 15 to 20 percent. The study also found that the drug accelerates aging, which also increases heart attack risks.
- Community-Acquired Pneumonia
Pneumonia is a severe type of lung infection, and community-acquired pneumonia describes being infected in a community setting. A study published in 2010 by The Pharmaceutical Journal found that the use of proton pump inhibitor drugs has been suggested as a risk factor for community-acquired pneumonia.
What Are the Claims Against PPI Manufacturers?
Drug manufacturers of heartburn and acid reflux medications such as Prevacid, Prilosec, and Nexium are facing thousands of drug injury lawsuits for the severe side effects caused by the medications. The lawsuits claim the medications were not properly tested and pharmaceutical companies failed to adequately warn patients and doctors of the harmful risks.
Our team will be reviewing PPI lawsuit leads for the following claims, that pharmaceutical companies:
- Manufactured a defective or dangerous drug
- Knowingly sold a defective or dangerous drug
- Failed to adequately warn patients and doctors about the risks of the drug
- Knowingly hid information about the harmful side effects of the drug
- Illegally marketed the drug
Research on the Dangers of PPI Drugs
In 2010, two separate studies found new concerns over the potential side effects of proton pump inhibitor use. The studies found that PPI drugs increase the risk of bone fractures, however the FDA determined that this risk only applies to patients taking high doses and over a long period of time. As a result, the FDA did not require additional warnings on PPI drug labels.
In 2016, a study published by JAMA’s Internal Medicine found that patients using PPI drugs have between a 20% and 50% increased risk for chronic kidney damage. Other studies during the same year found that the use of PPI drugs causes a 21% increased risk of stroke. It was also found that PPI users have a 50% higher 5-year death rate compared to other antacid medications such as H2 inhibitors.
In 2017, a study conducted by the Department of Veteran Affairs found more evidence of kidney damage linked to PPI drugs and that PPIs have a higher risk of kidney failure compared to H2 inhibitors. The study involved 125,596 patients taking PPIs and compared them to 18,436 people taking H2 inhibitors. About 10% of the patients taking PPI drugs developed chronic kidney disease, but less than half of those patients showed signs of kidney failure. Patients were at end-stage renal disease and required transplants or dialysis by the time kidney disease was detected. Around 7% of patients taking H2 inhibitors developed chronic kidney disease and only 1.3% developed kidney failure.
Who Are the Liable PPI Manufacturers
Many PPI patients have filed lawsuits against negligent pharmaceutical companies. Here are some of the companies and the PPI drugs they manufacture:
- Takeda Pharmaceuticals USA
- Bayer and Salix
- Proctor & Gamble
- Prilosec OTC
Broughton Partners will search for PPI lawsuit leads via our network of websites and targeted online advertising. Patients who have suffered from kidney damage after taking a PPI drug may be entitled to compensation for damages. Our team will review PPI lawsuit claims for the following damages:
- Medical expenses, both past and future
- Wages lost
- Pain and suffering
- Punitive damages
PPI Lawsuits & Settlement History
2011 – More than 30 residents of Texas filed a Nexium lawsuit against AstraZeneca claiming that the drug caused bone fractures and the company failed to warn patients of the severe side effects.
2012 – 47 Nexium lawsuits were consolidated in a Multidistrict Litigation (MDL) in the Central District of California that represented over 1,000 plaintiffs.
2014 – MDL ended in favor of AstraZeneca and officially closed on January 4, 2017. Later in 2014, the FDA approved a label change for Nexium and other proton pump inhibitor drugs that require stricter warning labels.
2015 – A critical lawsuit was filed against Prilosec and Nexium regarding their warning label. The plaintiff claimed that the warning label on the packages of these PPI drugs does not make it clear to consumers all of the side effects associated with taking the medications. AstraZeneca was sued for illegal marketing of their product because they created a generic version of these drugs to avoid liability and settled for $20 million. The PPI lawsuit, which can be claimed against AstraZeneca, aims at their failure to adequately warn consumers and doctors about the potentially severe side effects.
2016 – Pfizer settled Protonix lawsuits for $785 million to resolve allegations that the company failed to give the same discounts to Medicaid that were given to hospitals. The discounts were for Protonix Oral and Protonix IV.
2018 – 4,517 PPI lawsuits have been consolidated into MDL in New Jersey federal court. The lawsuits are scheduled to go on trial September 21, 2020, and are against the makers of Prilosec, Nexium, Prevacid, and Protonix. The number of PPI lawsuits continues to grow.
How Do We Find PPI Lawsuit Leads?
Our experienced in-house marketing team begins by targeting and connecting with victims that are searching for information about proton pump inhibitors and if they have a lawsuit. We then begin tracking PPI lawsuit leads with our industry-leading case-acquisition platform as soon as potential PPI plaintiffs show interest or call. Our system is constantly being updated and optimized so that only qualified leads are being delivered to law firms.
Our in-house call center is open and working 24 hours with multi-lingual specialists. Each of our intake associates is highly trained and knows how to handle intake sessions with quality and compassion. The PPI cases we come into contact with will be reviewed by our in-house call center via customized questions and a qualification process that is based on your law firm’s PPI case criteria.
When our team finds a qualified PPI lawsuit lead, we then gather appropriate case documents that your law firm will need to start working on the case right away.
Get More Than Just PPI Leads
Broughton Partners doesn’t just deliver retained PPI plaintiffs, we go further by providing PPI lawsuit leads ready with case documents such as hospital files and product information. We want to save your law firm’s time and provide everything you need to start working the case immediately. The PPI lawsuit leads that are provided by Broughton Partners are real victims who have legitimate PPI cases.
Finding PPI lawsuit leads can be difficult, especially qualified leads that have been reviewed for drug injury lawsuit eligibility. Broughton Partners will perform the time-consuming work of reviewing potential PPI leads and will only provide you with cases that meet your criteria.
Would you like to represent more claimants injured by PPI Drugs?
Bringing in new proton pump inhibitor cases in a cost-effective manner without sacrificing the needs of your current clients and the daily demands of your practice is a challenge at best. Broughton Partners is here to give you a competitive advantage by connecting you with qualified PPI injury cases that are ready and need your representation today.
Start reaching your goals and take your practice to the next level with new proton pump inhibitor injury lawsuit cases. Call Broughton Partners today at (855) 463-1735, or contact us for your free consultation. Together we can ensure there is No Claimant without a Claim.
- LeAnn W. O’Neill, PharmD. “Long-Term Consequences of Chronic Proton Pump Inhibitor Use”, U.S. Pharmacist, https://www.uspharmacist.com/article/longterm-consequences-of-chronic-proton-pump-inhibitor-use. Accessed February 5, 2019.
- Omudhome Ogbru, PharmD. “Proton Pump Inhibitors (PPIs) Side Effects, List of Names, and Uses”, https://www.medicinenet.com/proton-pump_inhibitors/article.htm#what_are_proton_pump_inhibitors_ppis_and_how_do_they_work_mechanism_of_action. Accessed February 5, 2019.
- Patrick Waring, MD. “Proton Pump Inhibitors (PPIs)”, International Foundation for Gastrointestinal Disorders, https://www.aboutgerd.org/medications/proton-pump-inhibitors-ppis.html. Accessed February 5, 2019.
- Choosing Wisely. “Treating Heartburn and GERD”, ABIM Foundation, http://www.choosingwisely.org/patient-resources/treating-heartburn-and-gerd/. Accessed February 5, 2019.
- Harvard Health Letter. “Proton-pump inhibitors”, Havard Health Publishing, https://www.health.harvard.edu/diseases-and-conditions/proton-pump-inhibitors. Accessed February 5, 2019.