When new medications for the treatment of HIV and AIDS came on the market in the 1990s and 2000s, the death sentence pronounced on many individuals diagnosed with these diseases was changed. Nucleoside reverse transcriptase inhibitors (NRTI) are HIV medicines that have turned what was once a deadly virus into a chronic condition that is now manageable.
In 2004, Truvada PrEP with TDF was introduced into the market to help treat HIV-positive adults in conjunction with other HIV medications like the NRTIs mentioned above. Truvada with TDF is taken to help keep HIV-negative adults from ever getting the virus. It has recently been approved for teens who test negative, as well. The use of the drug for teens is called Truvada for pre-exposure prophylaxis (PrEP.)
While the medication has been beneficial in protecting some individuals from acquiring HIV, it has proven to be harmful to others. Like other HIV drugs, Truvada with TDF can put people at a higher risk of dangerous side effects. It is crucial that individuals who are considering taking this medication understand the risks that go along with the drug.
The company that manufactures the drug is beginning to suffer repercussions in the form of lawsuits from people who started taking the medication and developed serious kidney problems. The lawsuits allege that Gilead Sciences Inc. manufactured a dangerous drug and did not advise the public of all the possible risks associated with taking the drug. Patients who have taken Truvada with TDF and developed kidney problems will be looking to file a drug injury lawsuit. Broughton Partners works to get your law firm connected with these Truvada lawsuit leads.
Get Signed & Case-Ready Truvada Lawsuit Leads
A powerful campaign of high-quality Truvada lawsuit leads will ensure that your law firm will have a steady stream of potential new cases and increased revenue. Victims of Truvada with TDF, or any other dangerous drug, can get the help they need through our network of websites and targeted online advertising.
Truvada lawsuit leads are hard to come by and signed cases are even more difficult to find. This is where Broughton Partners comes in. Your law firm can save precious time by letting our team use our marketing and legal expertise to communicate with potential plaintiffs. We perform the tedious work of vetting and examining potential defective hip replacement leads so that when we deliver your qualified cases you can begin working with the plaintiffs right away.
How Do We Find Truvada Lawsuit Leads?
Broughton Partners finds people who are injured and are actively seeking legal representation. We begin by using a proprietary case-acquisition platform to track leads online. Our system is constantly monitored and optimized to ensure only high-quality leads are being delivered to attorneys. Our 24/7 in-house call center is staffed by multi-lingual specialists who will fully examine each defective hip replacement lead for eligibility. We ask Truvada lawsuit leads a series of customized questions and run them through a qualification process that works with your law firm’s specified criteria. Once our team finds a legitimate defective hip replacement lead, we will go one step further by providing the necessary case documents such as hospital files and hip implant device information. Attorneys will then be able to begin working with their new clients and fight for their justice.
What is Truvada PrEP With TDF?
Truvada is a drug made from a combination of tenofovir disoproxil fumarate (TDF) and emtricitabine. As mentioned earlier, it is used with other medications in treating individuals who are infected with HIV. Truvada for PrEP is simply the name used when the drug is given alone to help protect people who are at high risk for HIV but are not yet infected.
HIV is the term used for the human immunodeficiency virus that attacks a person’s immune system. Individuals infected with HIV are left susceptible to contracting other infections easily. The virus finds and destroys a body’s T-helper cells by replicating a copy of itself inside those T-helper cells and then gradually taking over the entire immune system. Left untreated, the virus will completely destroy the person’s immune system. Of course, a body can only defend against diseases and infections with a healthy immune system, so if HIV is left untreated, it generally leads to death.
Untreated HIV will sometimes develop into AIDS (acquired immunodeficiency syndrome), a set of specific symptoms resulting from HIV in one’s body. An organization called Avert provides information and educational materials about HIV and AIDS, and it gives the following description of AIDS: “A person is said to have AIDS when their immune system is too weak to fight off infection, and they develop certain defining symptoms and illnesses. This is the last stage of HIV, when the infection is very advanced, and if left untreated, will lead to death.”
There is no known cure for AIDS or HIV. The currently available drugs are not a cure. However, they are a crucial part of an individual’s medical treatment and help give life-saving treatment options to patients who are HIV-positive. In many cases, these medications allow individuals to live much fuller and longer lives.
When Truvada with TDF is used to treat HIV-positive patients, the medication must be taken in combination with other HIV drugs to constitute a complete treatment option. For example, nucleoside reverse transcriptase inhibitors (NRTIs) are frequently used in conjunction with Truvada. Interestingly, NRTIs are the first medications approved for the treatment of HIV and are sometimes referred to as “nukes,” because they are so powerful and extremely effective in helping to manage HIV. A partial listing of some NRTIs that are currently on the market includes:
- Emtriva (emtricitabine)
- Viread (tenofovir)
- Ziagen (abacavir)
- Epivir (lamivudine)
- tenofovir alafenamide
Truvada with TDF is helpful in protecting people from getting HIV (Truvada for PrEP) and makes it harder for the virus to be passed along to others. Of course, it is still important for individuals to practice safe sex and continue the use of condoms, thereby helping to prevent the further spread of HIV.
TDF vs. TAF Drugs
Tenofovir disoproxil (TDF) and tenofovir alafenamide (TAF) are medications that are both used in the HAART regimen for HIV treatment. Both TDF and TAF medications are combined with other antiretroviral medications.
TDF is a commonly used agent for HIV treatment and was approved in 2001. While TDF is effective, the harmful side effects include bone mineral density reduction and nephrotoxicity. TDF, a prodrug, is administered into the body and then metabolized into the active drug tenofovir. The drug will travel through a patient’s body, to the plasma, and finally to the cell with the HIV virus. After entering the plasma, TDF has a half-life of around 20 to 30 seconds before it is metabolized into tenofovir. This means that a high percentage of the drug remains in the extracellular plasma where it is renally eliminated, this is the cause of nephrotoxicity.
TAF is Gilead Sciences’ new HIV medication formula that concentrates inside cells of the immune system and is generally perceived as safer than Truvada with TDF. This prodrug has a significantly longer half-life (90 minutes) than TDF after it enters the plasma. A longer half-life means that the prodrug has more time to enter the target HIV-infected cell. This leads to much higher intracellular concentrations of active tenofovir and greatly reduces extracellular concentrations. TAF has also shown in recent clinical trials to not cause nephrotoxicity or bone mineral density reduction. One study has shown that TAF medications have a 90% lower circulating tenofovir plasma concentration compared to TDF. This results in a lower risk of renal health problems.Different brands of combination medications that have previously been combined with TDF are being re-released as TAF medications. Some of these TAF medications are listed here:
- Descovy (TAF version of Truvada)
- Genvoya (TAF version of Stribild)
- Odefsey (TAF version of Complera
The major difference between the two HIV treatment medications is that TDF has much higher plasma tenofovir exposure, which can lead to serious health complications.
The Truvada cases that qualify for lawsuits only include Truvada with TDF and not TAF medications.
Side Effects and Deadly Complications
People taking Truvada PrEP with TDF to help control or prevent HIV have reported some serious side effects. It is reported that these side effects include kidney failure, and bone issue. Additionally, other more common side effects have been reported such as headaches, abdominal pain, diarrhea, weight loss, tiredness, nausea, dizziness, problems sleeping, and depression.
Because this medication can potentially cause worsening kidney problems that include kidney failure, a patient may want to have his or her blood tested before starting to take Truvada with TDF. Of course, if any kidney issues develop, a patient will most likely need to quit taking the medication.
Kidney problems that are left untreated may lead to kidney failure. Some of the symptoms of kidney failure are:
- Easy bleeding and bruising
- Fatigue and a drowsy feeling
- Trouble concentrating
- Lowered mental alertness
- Nausea and vomiting
- Less desire to eat
- Muscle twitching
- Muscle cramps
- Urinating at night
- Numb sensation in extremities
- Itchy skin or eyes
- Skin color changes
- Poor digestion
- Difficulty breathing due to fluid in the lungs
- Swelling and puffiness
- High blood pressure
- Decreased urine output
Another adverse effect of taking Truvada with TDF can be the development of bone problems. This can also be a signal that there is decreased kidney function. Among the symptoms of bone problems are:
- Pain in extremities
- Muscular pain or weakness
- Persistent or worsening bone pain
Sadly, these adverse effects can be extremely painful and could lead to more dangerous complications. There is even the potential for some of these side effects to lead to death if not treated by a medical provider. Patients who are taking Truvada with TDF and are suffering from any of these listed symptoms will need an experienced drug injury law firm to help them fight for compensation and to hold the drug manufacturer accountable for their injuries.
Taking Truvada With TDF
Truvada is administered as a tablet to be taken by mouth once a day. It may be taken with or without food, but it is important that it be taken around the same time every day as this helps to keep a consistent level of the drug in a patient’s bloodstream. If a dose is missed, this decreases the drug’s effectiveness by lowering the amount of the medication in the individual’s blood.
A doctor may perform tests like a Hepatitis B test and an HIV test on a patient before prescribing Truvada with TDF to help determine if the medicine is a viable and effective option. Additionally, if a person is using Truvada for PrEP to prevent HIV, he or she will likely be tested every three months for HIV while on the drug.
What Claims Are We Looking For With Truvada Lawsuit Leads
Broughton Partners will only deliver quality Truvada Lawsuit leads that are pre-qualified and match the case criteria specified by your law firm. This means that our team will only qualify Truvada PrEP with TDF (tenofovir disoproxil fumarate) cases and not Truvada with TAF cases. Our team of trained specialists will be examining the eligibility of cases and whether or not a patient’s claim qualifies for a Truvada with TDF lawsuit.
Our case intake system is built upon unique parameters and algorithms that allow us to dynamically improve case quality and conversion. We do this by running potential plaintiffs through specialized questions and a qualification process based on your law firm’s desired criteria. The Truvada lawsuit leads that your law firm will receive will be questioned and examined to ensure that they are quality retained plaintiffs.
Our team will be examining Truvada lawsuit leads for the following claims:
- The drug caused the plaintiff to develop chronic kidney disease or acute kidney failure
- The drug caused the plaintiff to develop osteoporosis
- Gilead Sciences Inc. failed to warn patients and doctors of potential severe side effects
- Gilead Sciences Inc. withheld a safer alternative drug, tenofovir alafenamide (TAF)
Broughton Partners Can Help Your Law Firm Find More Truvada Cases
Our case generation marketing firm can help you reach your goals by delivering prequalified Truvada lawsuit leads to your law firm. Broughton Partners provides you with plaintiffs who are fully qualified and meet your unique case criteria. Let us focus on what we do best, generating legal leads and delivering you signed cases, so you can spend more of your valuable time fighting and winning cases.
Call Broughton Partners today at (855) 463-1735, or contact us for your free consultation. Together we can ensure there is No Claimant without a Claim.
- RxList. “Truvada”, RxList, https://www.rxlist.com/truvada-side-effects-drug-center.htm. Accessed July 30, 2019.
- WebMD. “Truvada”, WebMD. https://www.webmd.com/drugs/2/drug-91482/truvada-oral/details. Accessed July 30, 2019.
- Ged Kenslea. “Gilead Lawsuits: California HIV Patients File Class Action and Personal Injury Cases Over Key HIV Drug”, AHF Newsroom, https://www.aidshealth.org/2018/05/gilead-lawsuits-california-hiv-patients-file-class-action-and-personal-injury-cases-over-key-hiv-drug/. Accessed July 30, 2019.
- Melody Petersen. “Patients sue Gilead, saying drug company intentionally delayed safer HIV medicine”, Los Angeles Times, https://www.latimes.com/business/la-fi-gilead-hiv-drug-lawsuit-20180509-story.html. Accessed July 30, 2019.
- Lou Chibbaro. “Gilead hit with more lawsuits over harmful side effects of AIDS drug”, Washington Blade, https://www.washingtonblade.com/2019/07/18/gilead-hit-with-more-lawsuits-over-harmful-side-effects-of-aids-drug/. Accessed July 30, 2019.