What is Truvada PrEP with TDF?

Truvada is a drug made from a combination of tenofovir disoproxil fumarate (TDF) and emtricitabine. As mentioned earlier, it is used with other medications in treating individuals who are infected with HIV. Truvada for PrEP is simply the name used when the drug is given alone to help protect people who are at high risk for HIV but are not yet infected.

HIV is the term used for the human immunodeficiency virus that attacks a person’s immune system. Individuals infected with HIV are left susceptible to contracting other infections easily. The virus finds and destroys a body’s T-helper cells by replicating a copy of itself inside those T-helper cells and then gradually taking over the entire immune system. Left untreated, the virus will completely destroy a person’s immune system. Of course, a body can only defend against diseases and infections with a healthy immune system, so if HIV is left untreated, it generally leads to death.

Untreated HIV will sometimes develop into AIDS (acquired immunodeficiency syndrome), a set of specific symptoms resulting from HIV in one’s body. An organization called Avert provides information and educational materials about HIV and AIDS, and it gives the following description of AIDS: “A person is said to have AIDS when their immune system is too weak to fight off infection, and they develop certain defining symptoms and illnesses. This is the last stage of HIV, when the infection is very advanced, and if left untreated, will lead to death.”

There is no known cure for AIDS or HIV. The currently available drugs are not a cure. However, they are a crucial part of an individual’s medical treatment and help give life-saving treatment options to patients who are HIV-positive. In many qualified retainers, these medications allow individuals to live much fuller and longer lives.

When Truvada with TDF is used to treat HIV-positive patients, the medication must be taken in combination with other HIV drugs to constitute a complete treatment option. For example, nucleoside reverse transcriptase inhibitors (NRTIs) are frequently used in conjunction with Truvada. Interestingly, NRTIs are the first medications approved for the treatment of HIV and are sometimes referred to as “nukes,” because they are so powerful and extremely effective in helping to manage HIV. A partial listing of some NRTIs that are currently on the market includes:

  • Emtriva (emtricitabine)
  • Viread (tenofovir)
  • Ziagen (abacavir)
  • Epivir (lamivudine)
  • tenofovir alafenamide

Truvada with TDF is helpful in protecting people from getting HIV (Truvada for PrEP) and makes it harder for the virus to be passed along to others. Of course, it is still important for individuals to practice safe sex and continue the use of condoms, thereby helping to prevent the further spread of HIV.

Truvada with TDF Linked to Bone and Kidney Problems

Truvada Causes Bone Problems

Side Effects

  • Fractures
  • Pain in extremities
  • Muscular pain or weakness
  • Persistent or worsening bone pain

Truvada Causes Kidney Damage

  • Anemia
  • Easy bleeding and bruising
  • Nausea and vomiting
  • Seizures
  • Muscle twitching or cramps
  • Itchy skin or eyes
  • Skin color changes
  • Diarrhea
  • Poor digestion
  • Difficulty breathing
  • High blood pressure

Truvada Lawsuit Claims

  • The drug caused the plaintiff to develop chronic kidney disease or acute kidney failure
  • The drug caused the plaintiff to develop osteoporosis
  • Gilead Sciences Inc. failed to warn patients and doctors of potentially severe side effects
  • Gilead Sciences Inc. withheld a safer alternative drug, tenofovir alafenamide (TAF)

Truvada with TDF Lawsuit

The company that manufactures Truvada with TDF is beginning to suffer repercussions in the form of lawsuits from people who started taking the medication and developed serious kidney problems. The lawsuits allege that Gilead Sciences Inc. manufactured a dangerous drug and did not advise the public of all the possible risks associated with taking the drug. Patients who have taken Truvada with TDF and developed kidney problems will be looking to file a drug injury lawsuit. Broughton Partners works to get your law firm connected with these Truvada lawsuit leads.

August 2004

Truvada with TDF was approved by the FDA.

July 2012

The FDA approved Truvada as a medication that will help reduce the risk of sexually acquired HIV infection in adults at high risk.

May 2018

The FDA approved Truvada to reduce the risk of sexually acquired HIV infection in adolescents weighing at least 77 lbs.

May 2018

The first few lawsuits against Gilead for the side effects of Truvada and other TDF-based HIV drugs were filed.

April 2019

8 patients who took Truvada with TDF and similar drugs filed a lawsuit against Gilead claiming that the company deliberately withheld a safer version of the drug. The plaintiffs allege that Gilead withheld Truvada with TAF until after their TDF patent expired to maximize profits.

July 2019

More lawsuits were filed against Gilead over the company’s decision to promote a dangerous drug before its patent expired when they had a safer alternative available. The AIDS Healthcare Foundation also demanded that Gilead create a $10 billion fund to help victims of Truvada with TDF.

References

RxList. “Truvada”, RxList. Accessed July 30, 2019.

WebMD. “Truvada”, WebMD. Accessed July 30, 2019.

Melody Petersen. “Patients sue Gilead, saying drug company intentionally delayed safer HIV medicine”, Los Angeles Times. Accessed July 30, 2019.

Lou Chibbaro. “Gilead hit with more lawsuits over harmful side effects of AIDS drug”, Washington Blade. Accessed July 30, 2019.

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